Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia

Abstract Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the impo...

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Main Authors: Lucille Stuani, Marie Sabatier, Jean-Emmanuel Sarry
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Biology
Online Access:http://link.springer.com/article/10.1186/s12915-019-0670-4
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spelling doaj-5342699d3bab49b686e214eb692bb3902020-11-25T03:07:19ZengBMCBMC Biology1741-70072019-07-0117111710.1186/s12915-019-0670-4Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaLucille Stuani0Marie Sabatier1Jean-Emmanuel Sarry2Centre de Recherches en Cancérologie de Toulouse, UMR1037, Inserm, Université de Toulouse 3 Paul Sabatier, Equipe Labellisée LIGUE 2018Centre de Recherches en Cancérologie de Toulouse, UMR1037, Inserm, Université de Toulouse 3 Paul Sabatier, Equipe Labellisée LIGUE 2018Centre de Recherches en Cancérologie de Toulouse, UMR1037, Inserm, Université de Toulouse 3 Paul Sabatier, Equipe Labellisée LIGUE 2018Abstract Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the importance of metabolism in cancer biology and how these changes might constitute an Achilles heel for cancer treatment. In this Review, we discuss the role of metabolic and mitochondrial pathways dysregulated in acute myeloid leukemia, and the potential of therapeutic intervention targeting these metabolic dependencies on the proliferation, differentiation, stem cell function and cell survival to improve patient stratification and outcomes.http://link.springer.com/article/10.1186/s12915-019-0670-4
collection DOAJ
language English
format Article
sources DOAJ
author Lucille Stuani
Marie Sabatier
Jean-Emmanuel Sarry
spellingShingle Lucille Stuani
Marie Sabatier
Jean-Emmanuel Sarry
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
BMC Biology
author_facet Lucille Stuani
Marie Sabatier
Jean-Emmanuel Sarry
author_sort Lucille Stuani
title Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
title_short Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
title_full Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
title_fullStr Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
title_full_unstemmed Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
title_sort exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
publisher BMC
series BMC Biology
issn 1741-7007
publishDate 2019-07-01
description Abstract Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the importance of metabolism in cancer biology and how these changes might constitute an Achilles heel for cancer treatment. In this Review, we discuss the role of metabolic and mitochondrial pathways dysregulated in acute myeloid leukemia, and the potential of therapeutic intervention targeting these metabolic dependencies on the proliferation, differentiation, stem cell function and cell survival to improve patient stratification and outcomes.
url http://link.springer.com/article/10.1186/s12915-019-0670-4
work_keys_str_mv AT lucillestuani exploitingmetabolicvulnerabilitiesforpersonalizedtherapyinacutemyeloidleukemia
AT mariesabatier exploitingmetabolicvulnerabilitiesforpersonalizedtherapyinacutemyeloidleukemia
AT jeanemmanuelsarry exploitingmetabolicvulnerabilitiesforpersonalizedtherapyinacutemyeloidleukemia
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