Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation...

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Main Authors: Sheenu Sheela, Sawa Ito, Jeffrey R. Strich, Maura Manion, Celina Montemayor-Garcia, Hao-Wei Wang, Karolyn A. Oetjen, Kamile A. West, Austin J. Barrett, Mark Parta, Juan Gea-Banacloche, Steven M. Holland, Christopher S. Hourigan, Catherine Lai
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Leukemia Research Reports
Subjects:
Acute myeloid leukemia
Fusarium solani
Allogenic transplant
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048917300146
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spelling doaj-533f5c1509fe41648282b4e0677515392020-11-25T00:31:08ZengElsevierLeukemia Research Reports2213-04892017-01-018C4610.1016/j.lrr.2017.07.001Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infectionSheenu Sheela0Sawa Ito1Jeffrey R. Strich2Maura Manion3Celina Montemayor-Garcia4Hao-Wei Wang5Karolyn A. Oetjen6Kamile A. West7Austin J. Barrett8Mark Parta9Juan Gea-Banacloche10Steven M. Holland11Christopher S. Hourigan12Catherine Lai13Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USAStem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USALaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USALaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USADepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USALaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAMyeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USADepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USAStem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USAClinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD 21702, USAExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USALaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAMyeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USAMyeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USADisseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.http://www.sciencedirect.com/science/article/pii/S2213048917300146Acute myeloid leukemiaFusarium solaniAllogenic transplant
collection DOAJ
language English
format Article
sources DOAJ
author Sheenu Sheela
Sawa Ito
Jeffrey R. Strich
Maura Manion
Celina Montemayor-Garcia
Hao-Wei Wang
Karolyn A. Oetjen
Kamile A. West
Austin J. Barrett
Mark Parta
Juan Gea-Banacloche
Steven M. Holland
Christopher S. Hourigan
Catherine Lai
spellingShingle Sheenu Sheela
Sawa Ito
Jeffrey R. Strich
Maura Manion
Celina Montemayor-Garcia
Hao-Wei Wang
Karolyn A. Oetjen
Kamile A. West
Austin J. Barrett
Mark Parta
Juan Gea-Banacloche
Steven M. Holland
Christopher S. Hourigan
Catherine Lai
Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
Leukemia Research Reports
Acute myeloid leukemia
Fusarium solani
Allogenic transplant
author_facet Sheenu Sheela
Sawa Ito
Jeffrey R. Strich
Maura Manion
Celina Montemayor-Garcia
Hao-Wei Wang
Karolyn A. Oetjen
Kamile A. West
Austin J. Barrett
Mark Parta
Juan Gea-Banacloche
Steven M. Holland
Christopher S. Hourigan
Catherine Lai
author_sort Sheenu Sheela
title Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
title_short Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
title_full Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
title_fullStr Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
title_full_unstemmed Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection
title_sort successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated fusarium solani infection
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2017-01-01
description Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.
topic Acute myeloid leukemia
Fusarium solani
Allogenic transplant
url http://www.sciencedirect.com/science/article/pii/S2213048917300146
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