Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation...

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Bibliographic Details
Main Authors: Sheenu Sheela, Sawa Ito, Jeffrey R. Strich, Maura Manion, Celina Montemayor-Garcia, Hao-Wei Wang, Karolyn A. Oetjen, Kamile A. West, Austin J. Barrett, Mark Parta, Juan Gea-Banacloche, Steven M. Holland, Christopher S. Hourigan, Catherine Lai
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Leukemia Research Reports
Subjects:
Acute myeloid leukemia
Fusarium solani
Allogenic transplant
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048917300146
Description
Summary:Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.
ISSN:2213-0489

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