Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration

Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration

Children with solid tumors represent a unique population. Recent improvements in pediatric solid tumor survival rates have been confined to low- and moderate-risk cancers, whereas minimal to no notable improvement in survival have been observed in high-risk and advanced-stage childhood tumors. The d...

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Bibliographic Details
Main Authors: Amos HP Loh, Rachel C Brennan, Walter H Lang, Robert J Hickey, Linda H Malkas, John Alexander Sandoval
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
Akt
PI3K
mTOR
signaling network
Pediatric solid tumors
Targeted biologic therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00093/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00093/full

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