Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104 L/mol.cm in metha...

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Main Authors: Alka Gupta, P. Mishra, K. Shah
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2009/956712
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spelling doaj-533bd65efe3746f1875360495131c8f12020-11-24T21:02:54ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102009-01-0161899210.1155/2009/956712Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical FormulationsAlka Gupta0P. Mishra1K. Shah2Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar (M.P.), IndiaGLA Institute of Pharmaceutical Research, Mathura-(U.P.), IndiaGLA Institute of Pharmaceutical Research, Mathura-(U.P.), IndiaA new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104 L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studieshttp://dx.doi.org/10.1155/2009/956712
collection DOAJ
language English
format Article
sources DOAJ
author Alka Gupta
P. Mishra
K. Shah
spellingShingle Alka Gupta
P. Mishra
K. Shah
Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
E-Journal of Chemistry
author_facet Alka Gupta
P. Mishra
K. Shah
author_sort Alka Gupta
title Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
title_short Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
title_full Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
title_fullStr Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
title_full_unstemmed Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations
title_sort simple uv spectrophotometric determination of rosuvastatin calcium in pure form and in pharmaceutical formulations
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2009-01-01
description A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104 L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies
url http://dx.doi.org/10.1155/2009/956712
work_keys_str_mv AT alkagupta simpleuvspectrophotometricdeterminationofrosuvastatincalciuminpureformandinpharmaceuticalformulations
AT pmishra simpleuvspectrophotometricdeterminationofrosuvastatincalciuminpureformandinpharmaceuticalformulations
AT kshah simpleuvspectrophotometricdeterminationofrosuvastatincalciuminpureformandinpharmaceuticalformulations
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