A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.

A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.

A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Gr...

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Bibliographic Details
Main Authors: Frank Jäkel, Oliver Worm, Sascha Lange, Roland Mertelsmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166954?pdf=render

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