A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.

A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.

A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Gr...

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Main Authors: Frank Jäkel, Oliver Worm, Sascha Lange, Roland Mertelsmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166954?pdf=render
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spelling doaj-533339a6fef74582aa5e1c98d15597292020-11-25T02:01:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020439310.1371/journal.pone.0204393A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.Frank JäkelOliver WormSascha LangeRoland MertelsmannA model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia.http://europepmc.org/articles/PMC6166954?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Frank Jäkel
Oliver Worm
Sascha Lange
Roland Mertelsmann
spellingShingle Frank Jäkel
Oliver Worm
Sascha Lange
Roland Mertelsmann
A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
PLoS ONE
author_facet Frank Jäkel
Oliver Worm
Sascha Lange
Roland Mertelsmann
author_sort Frank Jäkel
title A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
title_short A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
title_full A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
title_fullStr A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
title_full_unstemmed A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
title_sort stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia.
url http://europepmc.org/articles/PMC6166954?pdf=render
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