Therapeutic Drug Monitoring of Protein Unbound Ciprofloxacin Concentrations to avoid inadequate Treatment of severe Bacterial Infections in Critically ill Patients

Therapeutic Drug Monitoring of Protein Unbound Ciprofloxacin Concentrations to avoid inadequate Treatment of severe Bacterial Infections in Critically ill Patients

OBJECTIVES: To develop a reliable ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for therapeutic drug monitoring (TDM) of unbound ciprofloxacin concentrations in critically ill patients. METHODS: Total and unbound ciprofloxacin concentrations of five randomly s...

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Bibliographic Details
Main Authors: Nora J.D. Mabelis, Kimberly N. Shudofsky, Joost J. van Raaij, Sjoerd D. Meenks, Thomas Havenith, Sander Croes, Jos L.M.L. le Noble, Paddy K.C. Janssen
Format: Article
Language:English
Published: Betasciencepress Publishers 2018-12-01
Series:Journal of Applied Bioanalysis
Subjects:
ciprofloxacin
protein binding
mass spectrometry
UPLC-MS/MS
intensive care unit.
Online Access:https://doi.org/10.17145/jab.18.021

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