Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis

Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized mainly by arthritis, with the possible occurrence of extra-articular manifestations. We report the case of a patient who developed leptomeningitis as the first sign of RA, one year before the diagnosis of RA. Methylprednisolon...

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Main Authors: Mickaël Chouk, Alexandre Halb, Christine Mekhail, Amélie Godot, Frank Verhoeven, Clément Prati, Daniel Wendling
Format: Article
Language:English
Published: SMC MEDIA SRL 2021-04-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
rheumatoid arthritis
rheumatoid meningitis
rituximab
leptomeningitis
seizure
Online Access:https://www.ejcrim.com/index.php/EJCRIM/article/view/2358
id doaj-532d85038d674937995e047932f8aa92
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spelling doaj-532d85038d674937995e047932f8aa922021-04-23T09:48:09ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942021-04-0110.12890/2021_0023581974Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid ArthritisMickaël Chouk0Alexandre Halb1Christine Mekhail2Amélie Godot3Frank Verhoeven4Clément Prati5Daniel Wendling6Service de Rhumatologie, CHRU Besançon, Besançon, France Service de Neurologie, CHRU Besançon, Besançon, FranceService de Rhumatologie, CHRU Besançon, Besançon, France Service de Médecine Interne, CHRU Besançon, Besançon, FranceService de Rhumatologie, CHRU Besançon, Besançon, France Service de Rhumatologie, CHRU Besançon, Besançon, France Service de Rhumatologie, CHRU Besançon, Besançon, France Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized mainly by arthritis, with the possible occurrence of extra-articular manifestations. We report the case of a patient who developed leptomeningitis as the first sign of RA, one year before the diagnosis of RA. Methylprednisolone 1000 mg was given intravenously. Because of the onset of seizures and cognitive impairment, rituximab was started. After three cycles of rituximab (1000 mg on day 0 and 1000 mg on day 15, every 6 months), neurological clinical examination, MRI and electroencephalogram findings were significantly improved.https://www.ejcrim.com/index.php/EJCRIM/article/view/2358rheumatoid arthritisrheumatoid meningitisrituximableptomeningitisseizure
collection DOAJ
language English
format Article
sources DOAJ
author Mickaël Chouk
Alexandre Halb
Christine Mekhail
Amélie Godot
Frank Verhoeven
Clément Prati
Daniel Wendling
spellingShingle Mickaël Chouk
Alexandre Halb
Christine Mekhail
Amélie Godot
Frank Verhoeven
Clément Prati
Daniel Wendling
Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
European Journal of Case Reports in Internal Medicine
rheumatoid arthritis
rheumatoid meningitis
rituximab
leptomeningitis
seizure
author_facet Mickaël Chouk
Alexandre Halb
Christine Mekhail
Amélie Godot
Frank Verhoeven
Clément Prati
Daniel Wendling
author_sort Mickaël Chouk
title Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
title_short Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
title_full Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
title_fullStr Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
title_full_unstemmed Efficacy of Rituximab on Rheumatoid Leptomeningitis as the First Symptom of Rheumatoid Arthritis
title_sort efficacy of rituximab on rheumatoid leptomeningitis as the first symptom of rheumatoid arthritis
publisher SMC MEDIA SRL
series European Journal of Case Reports in Internal Medicine
issn 2284-2594
publishDate 2021-04-01
description Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized mainly by arthritis, with the possible occurrence of extra-articular manifestations. We report the case of a patient who developed leptomeningitis as the first sign of RA, one year before the diagnosis of RA. Methylprednisolone 1000 mg was given intravenously. Because of the onset of seizures and cognitive impairment, rituximab was started. After three cycles of rituximab (1000 mg on day 0 and 1000 mg on day 15, every 6 months), neurological clinical examination, MRI and electroencephalogram findings were significantly improved.
topic rheumatoid arthritis
rheumatoid meningitis
rituximab
leptomeningitis
seizure
url https://www.ejcrim.com/index.php/EJCRIM/article/view/2358
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AT christinemekhail efficacyofrituximabonrheumatoidleptomeningitisasthefirstsymptomofrheumatoidarthritis
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