Solvent-free copper-catalyzed click chemistry for the synthesis of N-heterocyclic hybrids based on quinoline and 1,2,3-triazole

Solvent-free copper-catalyzed click chemistry for the synthesis of N-heterocyclic hybrids based on quinoline and 1,2,3-triazole

Copper-catalyzed mechanochemical click reactions using Cu(II), Cu(I) and Cu(0) catalysts have been successfully implemented to provide novel 6-phenyl-2-(trifluoromethyl)quinolines with a phenyl-1,2,3-triazole moiety at O-4 of the quinoline core. Milling procedures proved to be significantly more eff...

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Bibliographic Details
Main Authors: Martina Tireli, Silvija Maračić, Stipe Lukin, Marina Juribašić Kulcsár, Dijana Žilić, Mario Cetina, Ivan Halasz, Silvana Raić-Malić, Krunoslav Užarević
Format: Article
Language:English
Published: Beilstein-Institut 2017-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
electron spin resonance (ESR) spectroscopy
in situ Raman monitoring
mechanochemistry
quinoline
solid-state click chemistry
Online Access:https://doi.org/10.3762/bjoc.13.232

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