Studies on anti-allergic activity of Sargassum horneri extract

Chlorophyll c2 in a Sargassum horneri extract suppressed the degranulation of rat basophilic leukaemia RBL-2H3 cells. In this contribution, the mode of action of S. horneri extract was revealed. The extract inhibited the elevation of intracellular Ca2+ concentration induced by the antigen. Immunoblo...

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Main Authors:	Hisashi Yoshioka, Momoko Ishida, Kosuke Nishi, Hiroshi Oda, Haruhiko Toyohara, Takuya Sugahara
Format:	Article
Language:	English
Published:	Elsevier 2014-09-01
Series:	Journal of Functional Foods
Subjects:	Anti-allergic activity Sargassum horneri Chlorophyll c2 Degranulation Syk phosphorylation RBL-2H3 cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S1756464614001935

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spelling	doaj-532ad202f47e40e38c0e3f42c89baf8a2021-04-29T04:42:43ZengElsevierJournal of Functional Foods1756-46462014-09-0110154160Studies on anti-allergic activity of Sargassum horneri extractHisashi Yoshioka0Momoko Ishida1Kosuke Nishi2Hiroshi Oda3Haruhiko Toyohara4Takuya Sugahara5Maruha Nichiro Holdings, Inc., Tsukuba, Ibaraki 300-4295, JapanFaculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, JapanFaculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, JapanMaruha Nichiro Holdings, Inc., Tsukuba, Ibaraki 300-4295, JapanDivision of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606-8502, JapanFaculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan; Food and Health Science Research Center, Faculty of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan; Corresponding author. Tel.: +81 89 946 9863; fax: +81 89 946 9863.Chlorophyll c2 in a Sargassum horneri extract suppressed the degranulation of rat basophilic leukaemia RBL-2H3 cells. In this contribution, the mode of action of S. horneri extract was revealed. The extract inhibited the elevation of intracellular Ca2+ concentration induced by the antigen. Immunoblot analysis showed that S. horneri extract down-regulated the phosphorylation of both Syk and PI3K in the signalling pathways involved in degranulation triggered by antigen–antibody interaction. In addition, oral administration of S. horneri extract inhibited mice nasal rubbing behaviour sensitized with anti-DNP IgE. These findings suggest that S. horneri extract has anti-allergic activity via the suppression of degranulation of mast cells and basophils.http://www.sciencedirect.com/science/article/pii/S1756464614001935Anti-allergic activitySargassum horneriChlorophyll c2DegranulationSyk phosphorylationRBL-2H3 cells
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hisashi Yoshioka Momoko Ishida Kosuke Nishi Hiroshi Oda Haruhiko Toyohara Takuya Sugahara
spellingShingle	Hisashi Yoshioka Momoko Ishida Kosuke Nishi Hiroshi Oda Haruhiko Toyohara Takuya Sugahara Studies on anti-allergic activity of Sargassum horneri extract Journal of Functional Foods Anti-allergic activity Sargassum horneri Chlorophyll c2 Degranulation Syk phosphorylation RBL-2H3 cells
author_facet	Hisashi Yoshioka Momoko Ishida Kosuke Nishi Hiroshi Oda Haruhiko Toyohara Takuya Sugahara
author_sort	Hisashi Yoshioka
title	Studies on anti-allergic activity of Sargassum horneri extract
title_short	Studies on anti-allergic activity of Sargassum horneri extract
title_full	Studies on anti-allergic activity of Sargassum horneri extract
title_fullStr	Studies on anti-allergic activity of Sargassum horneri extract
title_full_unstemmed	Studies on anti-allergic activity of Sargassum horneri extract
title_sort	studies on anti-allergic activity of sargassum horneri extract
publisher	Elsevier
series	Journal of Functional Foods
issn	1756-4646
publishDate	2014-09-01
description	Chlorophyll c2 in a Sargassum horneri extract suppressed the degranulation of rat basophilic leukaemia RBL-2H3 cells. In this contribution, the mode of action of S. horneri extract was revealed. The extract inhibited the elevation of intracellular Ca2+ concentration induced by the antigen. Immunoblot analysis showed that S. horneri extract down-regulated the phosphorylation of both Syk and PI3K in the signalling pathways involved in degranulation triggered by antigen–antibody interaction. In addition, oral administration of S. horneri extract inhibited mice nasal rubbing behaviour sensitized with anti-DNP IgE. These findings suggest that S. horneri extract has anti-allergic activity via the suppression of degranulation of mast cells and basophils.
topic	Anti-allergic activity Sargassum horneri Chlorophyll c2 Degranulation Syk phosphorylation RBL-2H3 cells
url	http://www.sciencedirect.com/science/article/pii/S1756464614001935
work_keys_str_mv	AT hisashiyoshioka studiesonantiallergicactivityofsargassumhorneriextract AT momokoishida studiesonantiallergicactivityofsargassumhorneriextract AT kosukenishi studiesonantiallergicactivityofsargassumhorneriextract AT hiroshioda studiesonantiallergicactivityofsargassumhorneriextract AT haruhikotoyohara studiesonantiallergicactivityofsargassumhorneriextract AT takuyasugahara studiesonantiallergicactivityofsargassumhorneriextract
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Studies on anti-allergic activity of Sargassum horneri extract

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