Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus

There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged a...

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Main Authors:	Jiajia Song, Ruilin Yang, Jing Yang, Lufang Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-12-01
Series:	Frontiers in Physiology
Subjects:	mitochondrial dysfunction arrhythmogenesis fibrosis redox signaling diabetes
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2018.01670/full

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spelling	doaj-532a929db23d440daea0d4caf18ba8dd2020-11-24T22:04:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-12-01910.3389/fphys.2018.01670420970Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes MellitusJiajia Song0Ruilin Yang1Ruilin Yang2Jing Yang3Lufang Zhou4Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesKey Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin, ChinaDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesThere is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy.https://www.frontiersin.org/article/10.3389/fphys.2018.01670/fullmitochondrial dysfunctionarrhythmogenesisfibrosisredox signalingdiabetes
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou
spellingShingle	Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus Frontiers in Physiology mitochondrial dysfunction arrhythmogenesis fibrosis redox signaling diabetes
author_facet	Jiajia Song Ruilin Yang Ruilin Yang Jing Yang Lufang Zhou
author_sort	Jiajia Song
title	Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
title_short	Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
title_full	Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
title_fullStr	Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
title_full_unstemmed	Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus
title_sort	mitochondrial dysfunction-associated arrhythmogenic substrates in diabetes mellitus
publisher	Frontiers Media S.A.
series	Frontiers in Physiology
issn	1664-042X
publishDate	2018-12-01
description	There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy.
topic	mitochondrial dysfunction arrhythmogenesis fibrosis redox signaling diabetes
url	https://www.frontiersin.org/article/10.3389/fphys.2018.01670/full
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Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus

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