Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus

• Main Authors: Limin Yin, Xiuhai Gan, Jing Shi, Ningning Zan, Awei Zhang, Xiaoli Ren, Miao Li, Dandan Xie, Deyu Hu, Baoan Song
• Format: Article
• Language: English
• Published: MDPI AG 2018-12-01
• Series: International Journal of Molecular Sciences
• Subjects: tobacco mosaic virus; curcumin analogs; quinazoline moiety; protective activity; plant induced resistance
• Online Access: https://www.mdpi.com/1422-0067/19/12/4065

Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protective activity. Inspired by these results, the active substructure of pentadienone and quinazoline were spliced to obtain curcumin analogs as potential exogenously induced resistant molecule. Bioassay results showed that compound <b>A13</b> exhibited excellent protective activity for tobacco to against Tobacco mosaic virus (TMV) at 500 &#956;g/mL, with a value of 70.4 &#177; 2.6% compared with control treatments, which was better than that of the plant immune activator chitosan oligosaccharide (49.0 &#177; 5.9%). The protective activity is due to compound <b>A13</b> inducing tobacco resistance to TMV, which was related to defense-related enzymes, defense-related genes, and photosynthesis. This was confirmed by the up-regulated expression of proteins that mediate stress responses and oxidative phosphorylation.