The Role of Non-Specific Interactions in Canonical and ALT-Associated PML-Bodies Formation and Dynamics

The Role of Non-Specific Interactions in Canonical and ALT-Associated PML-Bodies Formation and Dynamics

In this work, we put forward a hypothesis about the decisive role of multivalent nonspecific interactions in the early stages of PML body formation. Our analysis of the PML isoform sequences showed that some of the PML isoforms, primarily PML-II, are prone to phase separation due to their polyamphol...

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Bibliographic Details
Main Authors: Alexander V. Fonin, Sergey A. Silonov, Olesya G. Shpironok, Iuliia A. Antifeeva, Alexey V. Petukhov, Anna E. Romanovich, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
membrane-less organelles (MLOs)
PML-bodies
promyelocytic leukemia protein (PML) isoforms
acute hydrogen peroxide-induced oxidative stress
fluorescence recovery after photobleaching (FRAP)
Online Access:https://www.mdpi.com/1422-0067/22/11/5821

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https://www.mdpi.com/1422-0067/22/11/5821

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