Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury

Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and...

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Main Authors:	Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Neural Plasticity
Online Access:	http://dx.doi.org/10.1155/2018/7513748

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spelling	doaj-5313af4f5525456f9488aeb06d4924322020-11-24T23:41:10ZengHindawi LimitedNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/75137487513748Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord InjuryJingying Zhou0Xue Huo1Benson O. A. Botchway2Luyao Xu3Xiaofang Meng4Songou Zhang5Xuehong Liu6Department of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaInstitute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, ChinaInstitute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, ChinaSpinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.http://dx.doi.org/10.1155/2018/7513748
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu
spellingShingle	Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury Neural Plasticity
author_facet	Jingying Zhou Xue Huo Benson O. A. Botchway Luyao Xu Xiaofang Meng Songou Zhang Xuehong Liu
author_sort	Jingying Zhou
title	Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
title_short	Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
title_full	Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
title_fullStr	Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
title_full_unstemmed	Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
title_sort	beneficial effects of resveratrol-mediated inhibition of the mtor pathway in spinal cord injury
publisher	Hindawi Limited
series	Neural Plasticity
issn	2090-5904 1687-5443
publishDate	2018-01-01
description	Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.
url	http://dx.doi.org/10.1155/2018/7513748
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury

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