| Summary: | 【Abstract】 Objective: The effect of tranexamic acid
(TA) on patients receiving total knee arthroplasty (TKA)
has been reported in many small clinical trials. But single
trials are not sufficient enough to clarify the effectiveness
and safety of TA. So, we carried out a meta-analysis of
randomized controlled trials to investigate the efficacy and
safety of the intravenous use of TA in TKA.
Methods: Literatures were retrieved in Cochrane
Library, OVID, PubMed, EMBASE, CNKI and Wanfang Data.
All the related literatures were checked by two independent
investigators and only the high quality randomized con-trolled trials were enrolled. Relevant data were analyzed
using RevMan 5.1 to compare the difference of blood loss,
transfusion and complications between TA group and con-trol group.
Results: There were 353 related literatures and only 22
randomized controlled trials met the inclusion criteria. The
use of TA in TKA significantly reduced total blood loss by
a mean of 435.41 ml (95% CI 300.62-570.21, P<0.01), post-operative blood loss by a mean of 406.69 ml (95% CI 333.16-480.22, P<0.01). TA also significantly lowered the transfu-sion rate (risk difference 0.30, 95% CI 0.21-0.39, P<0.01) and
transfusion volume (mean difference 0.95 unit, 95% CI 0.53-1.37, P<0.01). The risks between TA group and control group
in developing deep vein thrombosis and pulmonary embo-lism were not statistically significant.
Conclusion: TA is beneficial for patients undergoing
TKA, which can significantly reduce total blood loss, post-operative blood loss, transfusion rate, and transfusion
volume. Meanwhile TA is recommended to reduce deep vein
thrombosis and pulmonary embolism following TKA.
Key words: Tranexamic acid; Arthroplasty; Knee;
Blood loss, surgical; Meta-analysis
|
|---|
