Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

Abstract Background Hepatitis B virus (HBV) infection is difficult to cure. HBV-specific immune tolerance plays a key role in HBV persistence, and enhancing cellular and humoral immunity will improve the control of HBV infection. The purpose of the study was to explore the anti-HBV and immunostimula...

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Bibliographic Details
Main Authors: Tingyu Lan, Zhiqiang Wei, Yulin He, Song Wan, Li Liu, Bin Cheng, Ruimin Li, Hongxia Chen, Guohua Liu, Zhongji Meng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Virology Journal
Subjects:
Hepatitis B virus
RNAi
microRNA-like siRNA
msiRNA
Immunostimulation
Innate immunity
Online Access:https://doi.org/10.1186/s12985-021-01509-z

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