Effect of L-Arginine on glomerular endotheliosis improvement in preeclampsia

• Main Authors: Sri Sulistyowati, Nengah Budiarta, Soetrisno Soetrisno
• Format: Article
• Language: English
• Published: DiscoverSys 2017-07-01
• Series: Bali Medical Journal
• Subjects: l-arginine, glomerular endotheliosis, preeclampsia.
• Online Access: https://balimedicaljournal.org/index.php/bmj/article/view/672
• ISSN: 2089-1180; 2302-2914

<p>Background: Preeclampsia is the leading cause of morbidity and mortality in pregnant women and the fetus. In preeclampsia, glomerular endotheliosis occurs due to endothelium dysfunction in the kidney. Supplementation with L-Arginine is postulated to improve glomerular endotheliosis. The aim of this study is to investigate the effect of L-Arginine on improving glomerular endotheliosis in an animal model of preeclampsia.</p><p>Method: This is an analytical experiment research which was conducted in November 2016 to January 2017 in Biomedical Laboratory Faculty of Veterinary Medicine, University of Airlangga, Surabaya. Thirty pregnant mice (<em>Mus musculus</em>) were used in this research. The mice were divided equally into three groups, normal pregnant mice (K1), pregnant mice model of preeclampsia (K2), and preeclampsia pregnant mice treated with L-Arginine (K3). The kidneys were then obtained surgically and examined with immunohistochemistry examination. Data were analyzed by using one-way ANOVA and Post-hoc test.</p><p>Results: The mean score of glomerular endotheliosis were 0.44±0.42 for K1, 1.34±0 for K2, and 0.62±0.45 for K3. There was a significant difference between K1 and K2 (<em>p=</em>0.0000), and also between K2 and K3 (<em>p</em>=0,000).</p><p>Conclusion: L-Arginine is effective on improving glomerular entoheliosis in a mouse model of preeclampsia. </p>