Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells

Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells

Background/Aims: HER2 has been implicated in mammary tumorigenesis as well as aggressive tumor growth and metastasis. Its overexpression is related to a poor prognosis and chemoresistance in breast cancer patients. Although Grb2-associated binding protein 2 (Gab2) is important in the development and...

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Bibliographic Details
Main Authors: Peng Zhang, Yiying Chen, Miaomiao Gong, Zhumei Zhuang, Yueyue Wang, Lin Mu, Tianjiao Wang, Jinjin Pan, Yanan Liu, Jianming Xu, Rui Liang, Yuhui  Yuan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Gab2
HER2
Cancer stem cells
Breast cancer
Online Access:https://www.karger.com/Article/FullText/493957

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