Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

• Main Authors: Liboni William, Negri Emanuela, Mana Ornella, Allais Gianni, Benedetto Chiara, Molinari Filippo, Rosati Samanta
• Format: Article
• Language: English
• Published: SpringerOpen 2010-01-01
• Series: EURASIP Journal on Advances in Signal Processing
• Online Access: http://asp.eurasipjournals.com/content/2010/459213

<p>Abstract</p> <p>Near-infrared spectroscopy (NIRS) is a noninvasive system for the real-time monitoring of the concentration of oxygenated (<inline-formula> <graphic file="1687-6180-2010-459213-i1.gif"/></inline-formula>) and reduced (HHb) hemoglobin in the brain cortex. <inline-formula> <graphic file="1687-6180-2010-459213-i2.gif"/></inline-formula> and HHb concentrations vary in response to cerebral autoregulation. Sixty-eight women (14 migraineurs without aura, 49 migraineurs with aura, and 5 controls) performed breath-holding and hyperventilation during NIRS recordings. Signals were processed using the Choi-Williams time-frequency transform in order to measure the power variation of the very-low frequencies (VLF: 20&#8211;40&#8201;mHz) and of the low frequencies (LF: 40&#8211;140&#8201;mHz). Results showed that migraineurs without aura present different LF and VLF power levels than controls and migraineurs with aura. The accurate power measurement of the time-frequency analysis allowed for the discrimination of the subjects' hemodynamic patterns. The time-frequency analysis of NIRS signals can be used in clinical practice to assess cerebral hemodynamics.</p>