DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
Formation of γH2Ax serves as a checkpoint for double-strand break (DSB) repair pathways. Here the authors reveal via integrated chromatin analysis that γH2Ax domains are established by chromosomal contacts with the DSB site.
Bibliographic Details
| Main Authors: |
Patrick L. Collins,
Caitlin Purman,
Sofia I. Porter,
Vincent Nganga,
Ankita Saini,
Katharina E. Hayer,
Greer L. Gurewitz,
Barry P. Sleckman,
Jeffrey J. Bednarski,
Craig H. Bassing,
Eugene M. Oltz |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2020-06-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-16926-x
|
|---|
