Taste Masking of Nizatidine Using Ion-Exchange Resins

• Main Authors: Pattaraporn Panraksa, Kasidech Boonsermsukcharoen, Kyu-Mok Hwang, Eun-Seok Park, Pensak Jantrawut
• Format: Article
• Language: English
• Published: MDPI AG 2019-10-01
• Series: Processes
• Subjects: nizatidine; ion-exchange resins; dowex; amberlite; electronic tongue
• Online Access: https://www.mdpi.com/2227-9717/7/11/779

The purpose of this study was to mask the bitter taste of nizatidine (NZD) using cation-exchange resins. Amberlite IRP-69 and Dowex-50 containing cross-linked polystyrene backbones were used. The drug resin complexes were prepared by batch process using drug: resin ratios of 1:1, 1:3, and 1:5. The optimum drug: resin ratio and the time required for maximum percentage drug loading into the complexes were determined. The selected drug-resin complexes were evaluated for morphology, drug release, and taste. The NZD-Dowex complex was obtained at a drug: resin ratio of 1:5 using a stirring time of 1 h in order to get 100% loading of NZD. The NZD-Dowex complex had a spherical shape and smooth texture similar to Dowex resin. The NZD-Dowex complex with a ratio of 1:5 showed that in vitro drug release of 4.27% at 5 min in simulated salivary fluid of pH 6.8 and 99.67% at 1 h in simulated gastric fluid of pH 1.2. NZD’s bitter taste was effectively masked when it formed a complex with Dowex at a ratio of 1:5. This was proved by an electronic tongue and human test panel.