Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC-MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different...

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Bibliographic Details
Main Authors: Xiaoming Liang, Zhenzhen Liu, Huiyan Shi, Yuanyuan Zhang, Shixiao Wang, Kaishun Bi, Xiaohui Chen
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Larotaxel
Degradation kinetics
pH
Temperature
Degradation products
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177916301216

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