Enhanced 4-Hydroxynonenal Resistance in KEAP1 Silenced Human Colon Cancer Cells

Enhanced 4-Hydroxynonenal Resistance in KEAP1 Silenced Human Colon Cancer Cells

Nuclear factor erythroid 2-related factor 2 (NRF2) is the transcription factor that regulates an array of antioxidant/detoxifying genes for cellular defense. The conformational changes of Kelch-like ECH-associated protein 1 (KEAP1), a cytosolic repressor protein of NRF2, by various stimuli result in...

Full description

Bibliographic Details
Main Authors:	Kyeong-Ah Jung, Mi-Kyoung Kwak
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2013/423965

Similar Items

Peroxynitrite and 4-Hydroxynonenal Inactivate Breast Cancer Resistance Protein/ABCG2
by: Svetlana Verenich, et al.
Published: (2019-01-01)

4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia
by: Ichiya Sano, et al.
Published: (2013-01-01)

Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells
by: Sujin Lee, et al.
Published: (2019-06-01)

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
by: Huiqin Zhong, et al.
Published: (2015-04-01)

In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism
by: Igor Petkovic, et al.
Published: (2020-02-01)

Astrocytes Accumulate 4-Hydroxynonenal Adducts in Murine Scrapie and Human Creutzfeldt–Jakob Disease
by: Olivier Andreoletti, et al.
Published: (2002-12-01)

Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
by: Balu K. Chacko, et al.
Published: (2016-10-01)

4-Hydroxynonenal Immunoreactivity Is Increased in the Frontal Cortex of 5XFAD Transgenic Mice
by: Sang-Wook Shin, et al.
Published: (2020-09-01)

Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product
by: W G Siems, et al.
Published: (1997-03-01)

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress
by: Ganka Bekyarova, et al.
Published: (2019-01-01)

Ribonucleotide reductase in dividing cells : purification and inhibition studies with 4-hydroxynonenal
by: Li, Li
Published: (1992)

The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing.
by: Bo-hyun Choi, et al.
Published: (2014-01-01)

Association of aspirin resistance with 4‐hydroxynonenal and its impact on recurrent cerebral infarction in patients with acute cerebral infarction
by: Juan Guo, et al.
Published: (2020-03-01)

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
by: Stefania Pizzimenti, et al.
Published: (2010-03-01)

Increased 4-hydroxynonenal formation contributes to obesity-related lipolytic activation in adipocytes.
by: Ximei Zhang, et al.
Published: (2013-01-01)

Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders
by: Giuseppina Barrera, et al.
Published: (2018-07-01)

4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach in Health and Diseases
by: Andriy Cherkas, et al.
Published: (2018-09-01)

Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder
by: Matea Nikolac Perković, et al.
Published: (2021-09-01)

Structural and functional changes in LDL after modification with both 4-hydroxynonenal and malondialdehyde
by: HF Hoff, et al.
Published: (1993-07-01)

Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
by: Wogan, Gerald N., et al.
Published: (2010)

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors
by: Angelo Sparaneo, et al.
Published: (2019-05-01)

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants
by: Mi-Kyoung Kwak, et al.
Published: (2010-10-01)

The Lipid Peroxidation End-Product 4-Hydroxynonenal Induces Insulin Resistance in Isolated Rat Slow-Twitch Skeletal Muscle
by: Giovannini, Franchesca J., et al.
Published: (2013)

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells
by: Yi-Fen Chiang, et al.
Published: (2020-11-01)

4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation
by: Audrey Swiader, et al.
Published: (2021-02-01)

“Twin peaks”: Searching for 4-hydroxynonenal urinary metabolites after oral administration in rats
by: Julia Keller, et al.
Published: (2015-04-01)

Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression
by: Evelin Schwarzer, et al.
Published: (2015-01-01)

Malaria Pigment Hemozoin Impairs GM-CSF Receptor Expression and Function by 4-Hydroxynonenal
by: Oleksii Skorokhod, et al.
Published: (2021-08-01)

Inhibitory role of the KEAP1-NRF2 pathway in TGFβ1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling.
by: In-Geun Ryoo, et al.
Published: (2014-01-01)

Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal
by: E.M. Shonsey, et al.
Published: (2008-02-01)

Methylation of the <it>KEAP1 </it>gene promoter region in human colorectal cancer
by: Hanada Naoyuki, et al.
Published: (2012-02-01)

The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte
by: Bettina P. Mihalas, et al.
Published: (2017-07-01)

Serum Concentrations of F-Isoprostanes and 4-Hydroxynonenal in Hemodialysis Patients in Relation to Inflammation and Renal Anemia
by: Ingrid Wiswedel, et al.
Published: (2008-01-01)

Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products
by: Mario Allegra, et al.
Published: (2020-05-01)

Oxidative Stress in the Male Germline: A Review of Novel Strategies to Reduce 4-Hydroxynonenal Production
by: Jessica L. H. Walters, et al.
Published: (2018-10-01)

Rôle du 4-hydroxynonénal dans la régulation du métabolisme des chondrocytes arthrosiques
by: Côté, Véronique
Published: (2012)

Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal
by: D'Souza, YOHAN
Published: (2013)

Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal
by: D'Souza, YOHAN
Published: (2013)

Rôle du 4-hydroxynonénal dans la régulation du métabolisme des chondrocytes arthrosiques
by: Côté, Véronique
Published: (2012)

Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney
by: T Grune, et al.
Published: (1997-08-01)

Cannot write session to /tmp/vufind_sessions/sess_32s7ocdv66uu15qfciopd036ps