Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1)...

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Bibliographic Details
Main Authors: Sandip Chorghade, Joseph Seimetz, Russell Emmons, Jing Yang, Stefan M Bresson, Michael De Lisio, Gianni Parise, Nicholas K Conrad, Auinash Kalsotra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
post-transcriptional gene regulation
translation control
polyadenylation
cardiac hypertrophy
postnatal heart development
protein synthesis
Online Access:https://elifesciences.org/articles/24139

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