Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study

Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study

Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection during childhood may polarise the immune system towards allergen-reactive Th2-type responses in genetically susceptible indivi...

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Bibliographic Details
Main Authors: Brian R. Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson, Barbara Young, Brian O’Connor
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Respiratory Research
Subjects:
Allergic asthma
Hygiene hypothesis
Type 1 interferon
Innate immune system
Online Access:https://doi.org/10.1186/s12931-019-1252-2

Internet

https://doi.org/10.1186/s12931-019-1252-2

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