The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis
Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its <i>Aedes</i> vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya vir...
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| Online Access: | https://www.mdpi.com/1999-4915/11/3/289 |
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doaj-52b2fcc4f7c94ebe97e503aeaa77057b2020-11-25T00:52:34ZengMDPI AGViruses1999-49152019-03-0111328910.3390/v11030289v11030289The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya ArthritisJ. Kennedy Amaral0Peter C. Taylor1Mauro Martins Teixeira2Thomas E. “Tem” Morrison3Robert T. Schoen4Department of Infectious Diseases and Tropical Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, BrazilNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, OX3 7LDR, UKDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, BrazilDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USASection of Rheumatology, Allery and Immunology, Yale University School of Medicine, New Haven, CT 06510, USAChikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its <i>Aedes</i> vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. Chronic CHIK arthritis (CCA) often causes severe pain and associated disability. The pathogenesis of CCA is not well understood. Proposed hypotheses include the persistence of a low level of replicating virus in the joints, the persistence of viral RNA in the synovium, and the induction of autoimmunity. In this review, we describe the main hypotheses of CCA pathogenesis, some of which support methotrexate (MTX) treatment which has been shown to be effective in preliminary studies in CCA.https://www.mdpi.com/1999-4915/11/3/289chikungunya viruschronic chikungunya arthritispathogenesismethotrexate |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
J. Kennedy Amaral Peter C. Taylor Mauro Martins Teixeira Thomas E. “Tem” Morrison Robert T. Schoen |
| spellingShingle |
J. Kennedy Amaral Peter C. Taylor Mauro Martins Teixeira Thomas E. “Tem” Morrison Robert T. Schoen The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis Viruses chikungunya virus chronic chikungunya arthritis pathogenesis methotrexate |
| author_facet |
J. Kennedy Amaral Peter C. Taylor Mauro Martins Teixeira Thomas E. “Tem” Morrison Robert T. Schoen |
| author_sort |
J. Kennedy Amaral |
| title |
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis |
| title_short |
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis |
| title_full |
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis |
| title_fullStr |
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis |
| title_full_unstemmed |
The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis |
| title_sort |
clinical features, pathogenesis and methotrexate therapy of chronic chikungunya arthritis |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2019-03-01 |
| description |
Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its <i>Aedes</i> vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. Chronic CHIK arthritis (CCA) often causes severe pain and associated disability. The pathogenesis of CCA is not well understood. Proposed hypotheses include the persistence of a low level of replicating virus in the joints, the persistence of viral RNA in the synovium, and the induction of autoimmunity. In this review, we describe the main hypotheses of CCA pathogenesis, some of which support methotrexate (MTX) treatment which has been shown to be effective in preliminary studies in CCA. |
| topic |
chikungunya virus chronic chikungunya arthritis pathogenesis methotrexate |
| url |
https://www.mdpi.com/1999-4915/11/3/289 |
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