Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression.

Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression.

Major mood disorders have been linked to abnormalities in circadian rhythms, leading to disturbances in sleep, mood, temperature, and hormonal levels. We provide evidence that ketamine, a drug with rapid antidepressant effects, influences the function of the circadian molecular machinery. Ketamine m...

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Bibliographic Details
Main Authors: Marina M Bellet, Marquis P Vawter, Blynn G Bunney, William E Bunney, Paolo Sassone-Corsi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3161090?pdf=render

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