Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

DNA damage causally contributes to aging and age-related diseases. The declining functioning of tissues and organs during aging can lead to the increased risk of succumbing to aging-associated diseases. Congenital syndromes that are caused by heritable mutations in DNA repair pathways lead to cancer...

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Bibliographic Details
Main Authors:	Diletta Edifizi, Björn Schumacher
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	International Journal of Molecular Sciences
Subjects:	DNA damage aging Nucleotide-excision repair (NER) Ultraviolet light (UV) Cockayne syndrome (CS) Xeroderma Pigmentosum (XP) growth hormone/insulin-like growth factor 1 (GH/IGF1) signaling autophagy protein homeostasis lipid metabolism
Online Access:	https://www.mdpi.com/1422-0067/18/11/2329

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