Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling

Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling

Sanguisorba officinalis L. (SA) is a common herb for cancer treatment in the clinic, particularly during the consolidation phase to prevent occurrence or metastasis. Nevertheless, there are limited studies reporting the molecular mechanisms about its anti-metastatic function. It is well demonstrated...

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Bibliographic Details
Main Authors: Neng Wang, Gulizeba Muhetaer, Xiaotong Zhang, Bowen Yang, Caiwei Wang, Yu Zhang, Xuan Wang, Juping Zhang, Shengqi Wang, Yifeng Zheng, Fengxue Zhang, Zhiyu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
breast-cancer metastasis
Sanguisorba officinalis L.
late-phase autophagic regulation
Cav-1
Hif-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.591400/full

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