Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate t...

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Bibliographic Details
Main Authors: Florine E. M. Scholte, Brian L. Hua, Jessica R. Spengler, John V. Dzimianski, JoAnn D. Coleman-McCray, Stephen R. Welch, Laura K. McMullan, Stuart T. Nichol, Scott D. Pegan, Christina F. Spiropoulou, Éric Bergeron
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
nairoviridae
rna replication
antiviral agents
bunyavirus
innate immunity
interferon-stimulated gene-15
proteases
ubiquitination
Online Access:https://doi.org/10.1128/mBio.01065-19

Internet

https://doi.org/10.1128/mBio.01065-19

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