The Need for Inducing Tolerance in Vascularized Composite Allotransplantation

The Need for Inducing Tolerance in Vascularized Composite Allotransplantation

Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression....

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Main Authors: Kadiyala V. Ravindra, Hong Xu, Larry D. Bozulic, David D. Song, Suzanne T. Ildstad
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/438078
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spelling doaj-528ed9632ec84a71b569835aacb49cfc2020-11-24T22:34:32ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/438078438078The Need for Inducing Tolerance in Vascularized Composite AllotransplantationKadiyala V. Ravindra0Hong Xu1Larry D. Bozulic2David D. Song3Suzanne T. Ildstad4Department of Surgery, Duke University Medical Center (DUMC) 3512, Durham, NC 27710, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USAInstitute for Cellular Therapeutics and Jewish Hospital, University of Louisville, 570 South Preston Street, Suite 404, Louisville, KY 40202-1760, USASuccessful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression. The unique immunological features of VCA such as split tolerance and resistance to chronic rejection are being investigated. Simultaneously there has been laboratory work studying tolerogenic protocols in animal VCA models. In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. This article reviews the immunology, animal models, mixed chimerism & tolerance induction in VCA and the direction of future research to enable better understanding and wider application of VCA.http://dx.doi.org/10.1155/2012/438078
collection DOAJ
language English
format Article
sources DOAJ
author Kadiyala V. Ravindra
Hong Xu
Larry D. Bozulic
David D. Song
Suzanne T. Ildstad
spellingShingle Kadiyala V. Ravindra
Hong Xu
Larry D. Bozulic
David D. Song
Suzanne T. Ildstad
The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
Clinical and Developmental Immunology
author_facet Kadiyala V. Ravindra
Hong Xu
Larry D. Bozulic
David D. Song
Suzanne T. Ildstad
author_sort Kadiyala V. Ravindra
title The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
title_short The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
title_full The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
title_fullStr The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
title_full_unstemmed The Need for Inducing Tolerance in Vascularized Composite Allotransplantation
title_sort need for inducing tolerance in vascularized composite allotransplantation
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2012-01-01
description Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression. The unique immunological features of VCA such as split tolerance and resistance to chronic rejection are being investigated. Simultaneously there has been laboratory work studying tolerogenic protocols in animal VCA models. In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. This article reviews the immunology, animal models, mixed chimerism & tolerance induction in VCA and the direction of future research to enable better understanding and wider application of VCA.
url http://dx.doi.org/10.1155/2012/438078
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