SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.

SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.

Maraviroc (MVC) gels are effective at protecting rhesus macaques from vaginal SHIV transmission, but breakthrough infections can occur. To determine the effects of a vaginal MVC gel on infecting SHIV populations in a macaque model, we analyzed plasma samples from three rhesus macaques that received...

Full description

Bibliographic Details
Main Authors:	Athe M N Tsibris, Urboshi Pal, Allison L Schure, Ronald S Veazey, Kevin J Kunstman, Timothy J Henrich, P J Klasse, Steven M Wolinsky, Daniel R Kuritzkes, John P Moore
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3229503?pdf=render

Similar Items

P03-10. Induction of neutralizing antibodies in Rhesus macaques following mucosal challenge with R5 tropic SHIV162P3 isolate
by: Montefiori D, et al.
Published: (2009-10-01)

Altered gene expression in asymptomatic SHIV-infected rhesus macaques (<it>Macacca mulatta</it>)
by: Phillips Aaron T, et al.
Published: (2006-09-01)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV.
by: Vickie A Marshall, et al.
Published: (2018-07-01)

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIV<sub>SF162P3N</sub> molecular clones in rhesus macaques
by: Ren Wuze, et al.
Published: (2013-01-01)

Characterization of CD49A+ NK cells in SIV/SHIV-infected rhesus macaques
by: Arias, Christian Fernando
Published: (2019)

Expression of pIgR in the tracheal mucosa of SHIV/SIV-infected rhesus macaques
by: Dong Li, et al.
Published: (2017-01-01)

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.
by: Giulia Calenda, et al.
Published: (2019-05-01)

Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
by: Anthony M. Cadena, et al.
Published: (2021-03-01)

Differential viral rebound between lymph node and colon after treatment interruption in SHIV-infected rhesus macaques
by: D.C. Hsu, et al.
Published: (2017-12-01)

Therapeutic efficacy of optimized eCD4-Ig proteins in SHIV-infected rhesus macaques
by: M.R. Gardner, et al.
Published: (2017-12-01)

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.
by: Nathalie Dereuddre-Bosquet, et al.
Published: (2012-01-01)

Immunoprofiling Correlates of Protection Against SHIV Infection in Adjuvanted HIV-1 Pox-Protein Vaccinated Rhesus Macaques
by: Pinyi Lu, et al.
Published: (2021-05-01)

Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques.
by: Jing Wen, et al.
Published: (2021-07-01)

Treatment of SHIV-infected, ART-suppressed rhesus macaques with bispecific HIVxCD3 DART® molecules
by: Daniel M. Gorman, et al.
Published: (2019-12-01)

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART.
by: Jesse D Deere, et al.
Published: (2014-01-01)

CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques
by: Naoki Saito, et al.
Published: (2014-01-01)

P19-08. Immunisation with recombinant HLA class I and II, HIV-1gp140 and SIVp27 antigens elicits protection against SHIV-SF162P4 infection in rhesus macaques
by: Schuitemaker H, et al.
Published: (2009-10-01)

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model.
by: Mehdi R M Bidokhti, et al.
Published: (2018-10-01)

Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant.
by: Maud Mavigner, et al.
Published: (2014-09-01)

Oral administration of a mixture of PR, RT and INT inhibitors to rhesus macaques that were persistently infected with SHIV-pr
by: Umehara Aya, et al.
Published: (2009-09-01)

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques.
by: Juan Pablo Jaworski, et al.
Published: (2017-01-01)

Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen.
by: Jessica Radzio, et al.
Published: (2012-01-01)

Identification of interdependent variables that influence coreceptor switch in R5 SHIV<sub>SF162P3N</sub>-infected macaques
by: Zhuang Ke, et al.
Published: (2012-12-01)

Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure.
by: Agnès-Laurence Chenine, et al.
Published: (2008-07-01)

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques
by: Rui-Rui Wang, et al.
Published: (2015-01-01)

Variations in the Biological Functions of HIV-1 Clade C Envelope in a SHIV-Infected Rhesus Macaque during Disease Progression.
by: For Yue Tso, et al.
Published: (2013-01-01)

Morphine Addiction Causes Pronounced Virus Replication in Cerebral Compartment and Accelerated Onset of AIDS in SIV/SHIV-infected Indian Rhesus Macaques
by: Staprans Silvija, et al.
Published: (2005-12-01)

Small intestine CD4+ cell reduction and enteropathy in SHIV-KS661-infected rhesus macaques in presence of low viral load
by: Inaba, Katsuhisa
Published: (2010)

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
by: Sampa Santra, et al.
Published: (2015-08-01)

Neonatal imitation in rhesus macaques.
by: Pier F Ferrari, et al.
Published: (2006-09-01)

Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution.
by: Robert C Kauffman, et al.
Published: (2014-01-01)

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.
by: Mayla Hsu, et al.
Published: (2014-01-01)

Assisted reproductive technologies in rhesus macaques
by: Wolf Don P
Published: (2004-06-01)

Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques.
by: Hong He, et al.
Published: (2011-01-01)

Repressive effect of primary virus replication on superinfection correlated with gut-derived central memory CD4(+) T cells in SHIV-infected Chinese rhesus macaques.
by: Jing Xue, et al.
Published: (2013-01-01)

R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.
by: Michael Santosuosso, et al.
Published: (2011-04-01)

Sustained SHIV reactivation by N-803 in ART-treated CD8-depleted macaques
by: J.B. McBrien, et al.
Published: (2019-07-01)

P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes
by: Devillers G, et al.
Published: (2009-10-01)

Isolation and characterization of intestinal epithelial cells from normal and SIV-infected rhesus macaques.
by: Diganta Pan, et al.
Published: (2012-01-01)

The Rhesus Macaque Corticospinal Connectome
by: Talmi, Sydney
Published: (2019)