miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury

miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury

Objective This study was designed to uncover the mechanism of miR-34b-5p-mediated aquaporin-2 (AQP2) in sepsis-induced injury using human renal tubular epithelial cells (HK-2). Methods Serum levels of miR-34b-5p, TNF-α, IL-1β, IL-6, serum creatinine (SCr), and blood urea nitrogen (BUN) in septic pat...

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Bibliographic Details
Main Authors: Caifa Zheng, Dansen Wu, Songjing Shi, Liming Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Renal Failure
Subjects:
mir-34b-5p
aquaporin-2
apoptosis
inflammation
sepsis
acute kidney injury
Online Access:http://dx.doi.org/10.1080/0886022X.2021.1871922

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