PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve

PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve

The lack of axonal regeneration is the major cause of vision loss after optic nerve injury in adult mammals. Activating the PI3K/AKT/mTOR signaling pathway has been shown to enhance the intrinsic growth capacity of neurons and to facilitate axonal regeneration in the central nervous system after inj...

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Bibliographic Details
Main Authors: Zheng-ru Huang, Hai-ying Chen, Zi-zhong Hu, Ping Xie, Qing-huai Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; optic nerve; axotomy; gene therapy; Mόller cell; retinal ganglion cell; AAV2; shRNA; PTEN; GLAST; mTOR; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=1;spage=135;epage=144;aulast=Huang

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