Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs

Clinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific c...

Full description

Bibliographic Details
Main Authors: Anthony M. Kyriakopoulos, Markus Nagl, Stella Baliou, Vasilleios Zoumpourlis
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/9632018
id doaj-527ad13f790b41fda397d4ba611a173a
record_format Article
spelling doaj-527ad13f790b41fda397d4ba611a173a2020-11-24T20:41:21ZengHindawi LimitedInternational Journal of Inflammation2090-80402042-00992017-01-01201710.1155/2017/96320189632018Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory DrugsAnthony M. Kyriakopoulos0Markus Nagl1Stella Baliou2Vasilleios Zoumpourlis3Nasco AD Biotechnology Laboratory, 11 Sachtouri Str, 18536 Pireus, GreeceDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstr. 41, 6020 Innsbruck, AustriaNational Hellenic Research Foundation, 48 Vas. Konstantinou Av., 11635 Athens, GreeceNational Hellenic Research Foundation, 48 Vas. Konstantinou Av., 11635 Athens, GreeceClinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. Materials and Methods. This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals. Results. Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition. Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs. In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided.http://dx.doi.org/10.1155/2017/9632018
collection DOAJ
language English
format Article
sources DOAJ
author Anthony M. Kyriakopoulos
Markus Nagl
Stella Baliou
Vasilleios Zoumpourlis
spellingShingle Anthony M. Kyriakopoulos
Markus Nagl
Stella Baliou
Vasilleios Zoumpourlis
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
International Journal of Inflammation
author_facet Anthony M. Kyriakopoulos
Markus Nagl
Stella Baliou
Vasilleios Zoumpourlis
author_sort Anthony M. Kyriakopoulos
title Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
title_short Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
title_full Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
title_fullStr Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
title_full_unstemmed Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
title_sort alleviating promotion of inflammation and cancer induced by nonsteroidal anti-inflammatory drugs
publisher Hindawi Limited
series International Journal of Inflammation
issn 2090-8040
2042-0099
publishDate 2017-01-01
description Clinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. Materials and Methods. This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals. Results. Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition. Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs. In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided.
url http://dx.doi.org/10.1155/2017/9632018
work_keys_str_mv AT anthonymkyriakopoulos alleviatingpromotionofinflammationandcancerinducedbynonsteroidalantiinflammatorydrugs
AT markusnagl alleviatingpromotionofinflammationandcancerinducedbynonsteroidalantiinflammatorydrugs
AT stellabaliou alleviatingpromotionofinflammationandcancerinducedbynonsteroidalantiinflammatorydrugs
AT vasilleioszoumpourlis alleviatingpromotionofinflammationandcancerinducedbynonsteroidalantiinflammatorydrugs
_version_ 1716825472622395392