Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
Clinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific c...
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Online Access: | http://dx.doi.org/10.1155/2017/9632018 |
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doaj-527ad13f790b41fda397d4ba611a173a2020-11-24T20:41:21ZengHindawi LimitedInternational Journal of Inflammation2090-80402042-00992017-01-01201710.1155/2017/96320189632018Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory DrugsAnthony M. Kyriakopoulos0Markus Nagl1Stella Baliou2Vasilleios Zoumpourlis3Nasco AD Biotechnology Laboratory, 11 Sachtouri Str, 18536 Pireus, GreeceDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstr. 41, 6020 Innsbruck, AustriaNational Hellenic Research Foundation, 48 Vas. Konstantinou Av., 11635 Athens, GreeceNational Hellenic Research Foundation, 48 Vas. Konstantinou Av., 11635 Athens, GreeceClinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. Materials and Methods. This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals. Results. Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition. Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs. In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided.http://dx.doi.org/10.1155/2017/9632018 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anthony M. Kyriakopoulos Markus Nagl Stella Baliou Vasilleios Zoumpourlis |
spellingShingle |
Anthony M. Kyriakopoulos Markus Nagl Stella Baliou Vasilleios Zoumpourlis Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs International Journal of Inflammation |
author_facet |
Anthony M. Kyriakopoulos Markus Nagl Stella Baliou Vasilleios Zoumpourlis |
author_sort |
Anthony M. Kyriakopoulos |
title |
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs |
title_short |
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs |
title_full |
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs |
title_fullStr |
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs |
title_full_unstemmed |
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs |
title_sort |
alleviating promotion of inflammation and cancer induced by nonsteroidal anti-inflammatory drugs |
publisher |
Hindawi Limited |
series |
International Journal of Inflammation |
issn |
2090-8040 2042-0099 |
publishDate |
2017-01-01 |
description |
Clinical Relevance. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. Materials and Methods. This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals. Results. Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition. Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs. In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided. |
url |
http://dx.doi.org/10.1155/2017/9632018 |
work_keys_str_mv |
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