Correlation of serum glutamyl transferase (GGT) and C-reactive protein (CRP) with angiogenesis and inflammation in patients with in-stent restenosis after PCI

• Main Authors: Jiao-Na Wei1, Rui-Hai Yang2, Yong-Jin Wang1, Hong-Yan Du3
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Percutaneous coronary intervention In-stent restenosis Glutamyl transferase C-reactive protein
• Online Access: http://www.hnykdxxb.com/PDF/201710/12.pdf

Objective: To study the correlation of serum glutamyl transferase (GGT) and C-reactive protein (CRP) with angiogenesis and inflammation in patients with in-stent restenosis after PCI. Methods: A total of 240 patients with acute coronary syndrome who received emergency PCI treatment in Cardiovascular Medicine Department of Hanzhong People’s Hospital between April 2013 and October 2016 were selected and divided into non-restenosis group and restenosis group after the occurrence of in-stent restenosis within 6 months after PCI was followed up. Before PCI as well as 3 d and 7 d after PCI, serum was collected to determine the levels of GGT, CRP, angiogenesis molecules and inflammatory cytokines. Results: Before PCI as well as 3 d and 7 d after PCI, serum GGT and CRP levels of restenosis group were significantly higher than those of non-restenosis group; 7 d after PCI, serum VEGF, Ang-1 and Ang-2 levels of restenosis group were significantly lower than those of non-restenosis group while IL-6 and IL-8 levels were significantly higher than those of non-restenosis group; serum VEGF, Ang-1 and Ang-2 levels of high GGT and CRP level groups were significantly lower than those of low GGT and CRP level groups while IL-6 and IL-8 levels were significantly higher than those of low GGT and CRP level groups. Conclusion: Preoperatively elevated serum GGT and CRP levels can aggravate the inflammation and inhibit the angiogenesis, and have predictive value for the in-stent restenosis after PCI.