Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway

Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway

Initial axonal elongation is essential for neuronal polarization and requires polarized activation of IGF-1 receptors (IGF-1r) and the phosphatidylinositol 3 kinase (PI3k) pathway. Wingless-type family growth factors (Wnts) have also been implied in the regulation of axonal development. It is not kn...

Full description

Bibliographic Details
Main Authors: Maria Eugenia Bernis, Mariana eOksdath, Sebastian eDupraz, Alvaro F. Nieto Guil, Marisa M. Fernandez, Emilio L. Malchiodi, Silvana B. Rosso, Santiago eQuiroga
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuronal polarity
axonal outgrowth
Wnt3a
IGF-1 receptor pathway
Frizzled-7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00194/full

Similar Items

Similar Items