| Summary: | A novel sesquiterpene dimer, spirocommiphorfuran A (<b>1</b>); two new cadinane sesquiterpenoids, commiphorenes A (<b>2</b>) and B (<b>3</b>); along with three known terpenoids (<b>4</b>⁻<b>6</b>), were isolated from <i>Resina</i> <i>Commiphora</i>. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound <b>1</b> features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound <b>2</b> is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon⁻carbon bond. Additionally, compounds <b>2</b> and <b>4</b> exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells.
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