Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patien...

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Main Authors: Vanya Slavcheva, T. Lukanov, G. Balatsenko, S. Angelova, А. Antonov, L. Bogdanov, N. Tsvetkov
Format: Article
Language:English
Published: PAGEPress Publications 2010-12-01
Series:Hematology Reports
Subjects:
Genetics
Klinefelter`s syndrome
Leukemia
Remission
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/2190
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spelling doaj-525b85a2161340d08f39679002df6bb82020-11-25T02:58:35ZengPAGEPress PublicationsHematology Reports2038-83222038-83302010-12-0121e11e1110.4081/hr.2010.e111345Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndromeVanya Slavcheva0T. LukanovG. BalatsenkoS. AngelovaА. AntonovL. BogdanovN. TsvetkovHematologist-University Hospital PlevenKlinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.http://www.pagepress.org/journals/index.php/hr/article/view/2190GeneticsKlinefelter`s syndromeLeukemiaRemission
collection DOAJ
language English
format Article
sources DOAJ
author Vanya Slavcheva
T. Lukanov
G. Balatsenko
S. Angelova
А. Antonov
L. Bogdanov
N. Tsvetkov
spellingShingle Vanya Slavcheva
T. Lukanov
G. Balatsenko
S. Angelova
А. Antonov
L. Bogdanov
N. Tsvetkov
Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
Hematology Reports
Genetics
Klinefelter`s syndrome
Leukemia
Remission
author_facet Vanya Slavcheva
T. Lukanov
G. Balatsenko
S. Angelova
А. Antonov
L. Bogdanov
N. Tsvetkov
author_sort Vanya Slavcheva
title Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
title_short Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
title_full Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
title_fullStr Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
title_full_unstemmed Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
title_sort clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with klinefelter’s syndrome
publisher PAGEPress Publications
series Hematology Reports
issn 2038-8322
2038-8330
publishDate 2010-12-01
description Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
topic Genetics
Klinefelter`s syndrome
Leukemia
Remission
url http://www.pagepress.org/journals/index.php/hr/article/view/2190
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