Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patien...

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Bibliographic Details
Main Authors: Vanya Slavcheva, T. Lukanov, G. Balatsenko, S. Angelova, А. Antonov, L. Bogdanov, N. Tsvetkov
Format: Article
Language:English
Published: PAGEPress Publications 2010-12-01
Series:Hematology Reports
Subjects:
Genetics
Klinefelter`s syndrome
Leukemia
Remission
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/2190
Description
Summary:Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
ISSN:2038-8322
2038-8330

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