The Staphylococcus aureus Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation

The Staphylococcus aureus Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation

The extracellular adherence protein (Eap) of Staphylococcus aureus is a secreted protein known to exert a number of adhesive and immunomodulatory properties. Here we describe the intrinsic DNA binding activity of this multifunctional secretory factor. By using atomic force microscopy, we provide evi...

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Bibliographic Details
Main Authors: Janina Eisenbeis, Mona Saffarzadeh, Henrik Peisker, Philipp Jung, Nicolas Thewes, Klaus T. Preissner, Mathias Herrmann, Virginie Molle, Brian V. Geisbrecht, Karin Jacobs, Markus Bischoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus aureus
extracellular adherence protein
DNA aggregation
atomic force microscopy
neutrophil extracellular traps
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00235/full

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