Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

Abstract Background Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant stromal partners in breast tissue, local invasion of breast cancer leads to the proximity of can...

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Bibliographic Details
Main Authors: Xiaohui Wei, Sijing Li, Jinyong He, Hongzhi Du, Yang Liu, Wei Yu, Haolin Hu, Lifei Han, Chenfei Wang, Hongyang Li, Xin Shi, Meixiao Zhan, Ligong Lu, Shengtao Yuan, Li Sun
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell Communication and Signaling
Subjects:
Breast Cancer
PAI-1
PLOD2
Microenvironment
Metastasis
Collagen
Online Access:http://link.springer.com/article/10.1186/s12964-019-0373-z

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