Inhibition of CXCL1-CXCR2 axis ameliorates cisplatin-induced acute kidney injury by mediating inflammatory response

Inhibition of CXCL1-CXCR2 axis ameliorates cisplatin-induced acute kidney injury by mediating inflammatory response

One of the limiting side effects of cisplatin use in cancer chemotherapy is nephrotoxicity. Inflammation is now believed to play a major role in the pathogenesis of cisplatin-induced acute kidney injury (AKI), and the mediators of inflammation contribute to it. CXCL1 was recently reported to be involv...

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Bibliographic Details
Main Authors: Peng Liu, Xinxiu Li, Weixing Lv, Zhaojun Xu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CXCL1
CXCR2
Cisplatin
Acute kidney injury
Inflammation
P38
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219353156

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