Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

• Main Authors: Hsiu-Chuan Lee, Wen-Yi Cheng, Yi-Hao Hsu, Hsiu-Yueh Su, Brian E. T.-G. Huang, Yen-Kuang Lin, Wing P. Chan, Chien-Tien Su, Shih-Yi Huang
• Format: Article
• Language: English
• Published: Elsevier 2015-12-01
• Series: Journal of Functional Foods
• Subjects: Metabolic syndrome; n-3 long-chain polyunsaturated fatty acids; n-6/n-3 ratio
• Online Access: http://www.sciencedirect.com/science/article/pii/S1756464615000444
• ISSN: 1756-4646

Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters.