Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects

Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects

Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes. Triple-negative breast cancer (TNBC) is difficult to treat, pro-inflammatory, and highly metastatic. We demonstrate that TNBC cells express TLR9 and are re...

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Bibliographic Details
Main Authors: Elias O.U. Eteshola, Karenia Landa, Rachel E. Rempel, Ibtehaj A. Naqvi, E. Shelley Hwang, Smita K. Nair, Bruce A. Sullenger
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DAMPs
cfDNA
breast cancer
TNBC
nucleic acid scavengers
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001578

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