Diarrhoea in Patients with COVID-19

• Main Author: A. A. Sheptulin
• Format: Article
• Language: Russian
• Published: Gastro LLC 2020-12-01
• Series: Российский журнал гастроэнтерологии, гепатологии, колопроктологии
• Subjects: covid-19; diarrhoea; developmental mechanisms
• Online Access: https://www.gastro-j.ru/jour/article/view/520

Aim. Revision of possible causes of diarrhoea in patients with the COVID-19 infection.Key points. Apart from respiratory symptoms, patients with the COVID-19 infection may also express gastrointestinal complaints, more frequently of diarrhoea (2–40% incidence rate). The causes of diarrhoea may relate to the virus direct interaction with the angiotensin-converting enzyme 2 (ACE2) receptors in mucosa, its impact on the intestinal microbiota and therapeutic side effects. The possible occurrence of diarrhoea as a leading clinical manifestation of the coronavirus infection hampers its timely diagnosis. Published evidence on the impact of diarrhoea on the course of COVID-19 is contradictory.Conclusion. Epidemiological and clinical aspects of this problem require further research.