Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia

<p>Abstract</p> <p>Background</p> <p>A sizeable body of data demonstrates that membrane ICAM-1 (mICAM-1) plays a significant role in host defense in a site-specific fashion. On the pulmonary vascular endothelium, mICAM-1 is necessary for normal leukocyte recruitment dur...

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Bibliographic Details
Main Authors: Curtis Jeffery L, Standiford Theodore J, Samuelson Linda C, VanDussen Kelli L, Lin Yujing, Tolle Leslie, Preston Angela M, Du Ming, Monroy Yeni K, Mendez Michael P, Beck James M, Christensen Paul J, Paine Robert
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Respiratory Research
Online Access:http://respiratory-research.com/content/12/1/12

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http://respiratory-research.com/content/12/1/12

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