Molecular bases for the regulation of NKG2D ligands in cancer

Molecular bases for the regulation of NKG2D ligands in cancer

NKG2D is an activating receptor expressed by NK and T cells primarily involved in the elimination of transformed and infected cells. NKG2D ligands are self-proteins restrictedly expressed in healthy tissues, but induced in response to signaling pathways commonly associated with transformation. Proli...

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Bibliographic Details
Main Authors: Leticia eHuergo-Zapico, Andrea eAcebes-Huerta, Alejandro eLópez-Soto, Mónica eVilla-Álvarez, Ana Pilar eGonzalez-Rodriguez, Segundo eGonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
T cells
NK cell
Signaling Pathways
NKG2D
ULBP
MICA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00106/full

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