Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting

Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting

Sphingosine kinases 1 and 2 (SK1 and SK2) are proto-oncogenic isozymes expressed in many human tumors and associated with chemoresistance and poor prognosis. They are well-recognized therapy targets and their inhibition was shown to induce tumor volume reduction and chemosensitization in multiple ca...

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Bibliographic Details
Main Authors: Heba Alshaker, Qi Wang, Daniel Brewer, Dmitri Pchejetski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
sphingosine kinase
gene knockdown
DNA microarray
transcriptome
breast cancer
prostate cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00303/full

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